London, UK - Serena Williams will begin her Wimbledon challenge against French player Harmony Tan, who will be making her main-draw debut.

For 40-year-old Williams, a seven-time Wimbledon singles champion, there will be relief at avoiding a seed in the first round.

That was a possibility given that Williams is in the draw on a wildcard, having not played singles since suffering an ankle injury in her Wimbledon opener one year ago.

Instead, the 23-time grand slam winner will face the world number 113, who lost in the first round of the recent French Open – perhaps as soft a landing as Williams could have had.

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Wimbledon begins on Monday at the All England Club, with women's defending champion Ash Barty not involved after announcing a shock retirement in March.

Williams has returned to action this week at the Eastbourne International, winning through two rounds in doubles alongside Ons Jabeur, before the duo pulled out due to a knee injury for Jabeur.

Awaiting the winner of Williams versus Tan will be American Christina McHale or Spanish 32nd seed Sara Sorribes Tormo, while last year's runner-up Karolina Pliskova is a potential third-round obstacle.

American teen Coco Gauff, fresh off her high school graduation and a first grand slam final in Paris, drew Romanian Elena-Gabriela Ruse.

Estonia's Anett Kontaveit, who may struggle to live up to her billing as the second seed having never previously gone past round three, plays American Bernarda Pera first up.