Los Angeles, California - A doctor who supplied Friends star Matthew Perry with ketamine in the months before he fatally overdosed, musing to a fellow physician over "how much this moron will pay" for the drug, was jailed in California on Wednesday.

Salvador Plasencia (44) is the first of five people to face justice over Perry's 2023 death in the hot tub of his Los Angeles home.

Plasencia was ordered to serve 30 months in prison for supplying the drug to the actor – who had well-documented struggles with addiction – at grossly inflated prices.

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In a victim impact statement filed with the court, Perry's mother, Suzanne Perry, and his stepfather, Keith Morrison, said Plasencia – who did not supply the fatal dose of the drug – had neglected his duty as a doctor.

"Matthew's recovery counted on you saying NO," they wrote.

"Your motives? I can't imagine. A doctor whose life is devoted to helping people?"

Plasencia's attorneys, Karen Goldstein and Debra White, who had argued for a probationary sentence, said their client, who has surrendered his medical license, was filled with regret.

"He is not a villain. He is someone who made serious mistakes in his treatment decisions involving the off-label use of ketamine – a drug commonly used for depression that does not have uniform standards," they said after the sentencing.

"The mistakes he made over the 13 days during which he treated Mr. Perry will stay with him forever."

Another doctor, Mark Chavez, pleaded guilty in October to conspiring to distribute ketamine to Perry.

Plasencia allegedly bought ketamine off Chavez and sold it to the actor at hugely inflated prices.

"I wonder how much this moron will pay," Plasencia wrote in one text message presented by prosecutors.

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The four other people who have also admitted their part in supplying drugs to the actor will be sentenced over the coming months.

They include Jasveen Sangha, the alleged "Ketamine Queen" who supplied drugs to high-end clients and celebrities, who could be jailed for up to 65 years.

Perry's live-in personal assistant and another man pleaded guilty in August to charges of conspiracy to distribute ketamine.

The actor's lengthy struggles with substance addiction were well-documented, but his death at age 54 sent shockwaves through the global legions of Friends fans.

A criminal investigation was launched soon after an autopsy discovered he had high levels of ketamine – an anesthetic – in his system.

In a plea deal with prosecutors, Plasencia said he went to Perry's home to administer ketamine by injection and distributed 20 vials of the drug over a roughly two-week period in autumn 2023.

Perry had been taking ketamine as part of supervised therapy for depression.

But prosecutors say that before his death, he became addicted to the substance, which also has psychedelic properties and is a popular party drug.