Washington DC - A UPS cargo plane crashed on Tuesday evening near the Louisville International Airport shortly after takeoff, the Federal Aviation Administration said.

"UPS Flight 2976 crashed around 5:15 p.m. local time," the FAA said, identifying the aircraft as a McDonnell Douglas MD-11 departing Kentucky bound for Daniel K. Inouye International Airport in Honolulu, Hawaii.

UPS said in a statement that three crew members were on board the aircraft, but provided no information as to any casualties or injuries."

In a post shared via X, however, the Louisville Metro Police Department confirmed that there were "injuries reported."

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Law enforcement issued a shelter-in-place order for all locations within 5 miles, according to CNN.

Aerial footage of the crash site showed a long trail of debris as firefighters blasted water onto a conflagration, with smoke billowing from the disaster area.

A nearby building appeared to have sustained damage, possibly caused by the crash.

Last month, a cargo plane veered off the runway upon landing in Hong Kong, killing two people at the airport.

At least three people died and 11 more were injured after a UPS cargo plane crashed Tuesday as it was departing Louisville International Airport for Hawaii, Kentucky Governor Andy Beshear said.

"Right now we believe we have at least three fatalities. Now I believe that number is going to get larger. We have at least 11 injuries, some of them very significant that are being treated by local hospitals," Beshear told a press briefing on Tuesday night.

"Again, I think that that number will get larger."