Tulum, Mexico - Rose McGowan called Oprah Winfrey out on Twitter for her friendships with Harvey Weinstein and Russell Simmons.

Rose has been an outspoken advocate since the creation of the #MeToo and #TimesUp movements.

She's also publicly bashed the accused and anyone associated with the offenders.

On Sunday, Oprah was the target of the Charmed star's grievances.

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The rant came about after a clip from an interview between Dolly Parton and the former TV host went viral.

In it, the two speak about the country star's fight with depression and some fans felt Oprah tried to exploit and shame Dolly over her illness.

"I am glad more are seeing the ugly truth of @Oprah. I wish she were real, but she isn't. From being pals with Weinstein to abandoning & destroying Russell Simmon's victims, she is about supporting a sick power structure for personal gain, she is as fake as they come. #lizard," Rose tweeted with a picture of Oprah kissing Harvey on the cheek.

This isn't the first time Oprah was criticized for her friendships with the disgraced director and the Def Jam founder.

Harvey was one of the first in Hollywood to be accused of sexual misconduct and harassment by dozens of actresses.

Allegations against Russell began in 2017 before he fled to Bali, Indonesia where he now resides.

In 2018, Oprah claimed she had no knowledge of Weinstein's heinous behavior towards women, especially Rose.

Oprah was the executive producer on the documentary On the Record, which highlighted the accusations against Russell, but withdrew from the doc and claimed she found some inconsistencies in the account of one of Russell's accusers, Drew Dixon.