Mexico City, Mexico - Secretary of State Marco Rubio vowed Wednesday the US would ramp up strikes on cartels after blowing up an alleged drug boat he linked to Venezuela, but he assured Mexico of respect for its sovereignty.

In the highest-level meeting between the two neighbors since Donald Trump returned to the White House, Rubio met for an hour and a half in Mexico City with President Claudia Sheinbaum, who has calmly sought cooperation in the complicated relationship with Washington.

The visit came a day after Trump said US forces blew up an alleged drug boat in the Caribbean that he said belonged to a criminal organization tied to Venezuela's leftist President Nicolas Maduro, a nemesis of the US.

The attack, whose details could not be independently verified by AFP, marks a dramatic escalation by the US, which has for decades relied on routine policing operations rather than deadly force to seize drugs.

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Rubio said that the policy had failed as piecemeal seizures did not affect the bottom line of cartels.

The US "blew it up and it'll happen again. Maybe it's happening right now," Rubio told a news conference.

"These are not stockbrokers. These are not real estate agents who on the side deal a few drugs... If you're on a boat full of cocaine or fentanyl, whatever, headed to the United States, you're an immediate threat to the United States," he said.

"We're not going to sit back anymore and watch these people sail down the Caribbean like a cruise ship."

The attack has stirred jitters in Mexico, with some of Trump's allies in Congress having mused about military action against cartels south of the US border.

But Rubio instead praised Mexico's record, hailing the efforts by Sheinbaum.

The two countries said they would set up a working group to carry out promises of further cooperation both against cartels and on curbing migration.

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"It is the closest security cooperation we have ever had, maybe with any country, but certainly in the history of US-Mexico relations," Rubio said.

In a joint statement, the countries said their cooperation was "based on the principles of reciprocity, respect for sovereignty and territorial integrity, shared and differentiated responsibility, as well as mutual trust."

Sheinbaum comes from the political left but has sought a pragmatic relationship with Trump. She has said, however, that US military "intervention" was a red line.

Mexican Foreign Secretary Juan Ramon de la Fuente, asked about Tuesday's strike, said Mexico believed in "self-determination, non-intervention, and peaceful solution of controversies."

Rubio heads later Wednesday to Ecuador, led by right-wing ally Daniel Noboa.