Washington DC – Florida Governor Ron DeSantis filed papers to launch his 2024 presidential campaign Wednesday, signaling 18 months of acrimony ahead as he and Donald Trump lock horns in what is expected to be an bitter contest for the Republican nomination.

DeSantis was considered a rising Republican star, but has already been caught flat-footed by months of relentless attacks from the former president, who has surged into a commanding lead despite being engulfed in criminal investigations.

The 44-year-old governor filed his candidacy documentation with the Federal Election Commission hours ahead of his scheduled announcement in a livestreamed chat with billionaire Twitter owner Elon Musk on the social network's audio platform.

Pro-DeSantis political organization Never Back Down released a video to accompany the launch featuring the governor's November 2022 election victory speech, in which he vows that "Florida is where woke goes to die."

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"We chose facts over fear. We chose education over indoctrination. We weathered the storm," he says.

"We fight the woke in the schools. We fight the woke in the corporations, we will never ever surrender to the woke mob. We will be courageous and we will never back down."

Musk teased the 6:00 PM EST Twitter Spaces event in remarks to a conference hosted by the Wall Street Journal, promising it would be live and unscripted, with "real time questions and answers."

The announcement comes at the start of a three-day retreat in Miami for some of DeSantis's wealthiest donors, who will be briefed on the campaign before the governor hits several early voting states next week.

Long viewed as the most viable challenger to twice-impeached Trump, DeSantis is better known than most of the hopefuls in the chasing pack for the Republican nomination -- but still lacks the frontrunner's national profile.

The launch format on Twitter offers him a dual advantage – giving him precious access to Musk's 140 million followers, many of whom are in Trump's base; and if he wins the nomination, the attention of a chunk of younger, less conservative voters he will likely need for a shot at the White House.

DeSantis has used his platform as Florida's chief executive to burnish his conservative credentials, signing off on some 80 new state laws this spring, many targeting "woke indoctrination" in schools and other public institutions.

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They include a ban on the discussion of gender identity and sexual orientation in schools, a block on funding for efforts to promote diversity at public universities, and one of the most restrictive abortion laws in the country.

Never Back Down, which has been acting as the governor's de facto campaign arm, has a ground operation in most of the early nominating states and is making plans to expand.

But the launch comes with DeSantis's ratings in decline as a number of policy missteps have prompted disquiet about his readiness to take on Trump.

He faces the daunting task of closing an enormous polling gap, with Trump posting leads of close to 40 percentage points, despite being indicted on felony financial charges and being found liable for sexual abuse in a New York civil trial.

Behind the scenes, the Trump and DeSantis camps have been jostling to secure political endorsements from state lawmakers while, at the national level, Florida's congressional delegation has broken heavily for Trump.

Musk is a well-known DeSantis admirer, although he said Twitter would remain neutral on the nomination and that his hosting of the campaign launch should not be taken as an endorsement.

"I've said publicly that my preference, and I think the preference of most Americans, is... to have someone fairly normal in office," he said, without making any explicit criticism of Trump.

The former reality TV star was banned from Twitter after the 2021 assault on the US Capitol by his supporters, and has not posted since being reinstated in November.

Trump has been attacking DeSantis almost daily on his record, character, and fitness for office, but responded to Wednesday's announcement with relative restraint – simply posting favorable polling on his own online platform, Truth Social.

"Announcing on Twitter is perfect for Ron DeSantis. This way he doesn't have to interact with people and the media can't ask him any questions," a Trump aide said.